Research associate Immunopathology (2 years temporary contract)

Basel
21.10.2019 | Position with re­spon­si­bil­i­ties | 100%

Research associate Immunopathology (2 years temporary contract)

Roche Pharma Research and Early Development (pRED) translates extraordinary science into medical innovation through a diversity of technologies and talent located across seven research sites worldwide. We deliver on individual patient needs through a deep understanding of disease biology and the implementation of Personalized Healthcare strategies.

BiOmics (Biomarkers, Bioinformatics and Omics) and Pathology provides expert solutions to Pharma Research and Early Development (pRED) projects by generating and integrating molecular, cellular, tissue and functional data. This way, we deliver unique and holistic insights into drug safety and efficacy and enable informed decisions to bring the best drugs to patients.

You think “just contributing” is not enough? You would like to pave the way how we do drug safety assessment in future?

We are looking for an Associate within our immunopathology laboratory.

Core tasks and responsibilities:

  • Address fundamental scientific questions, be responsible for the design and execution of experimental work, and conduct data analysis.
  • Develop and run in vitro immune cell assays (cytokine release assays, purification and cultivation of PBMC, purification and differentiation of immune cell subsets, activation assays).
  • Perform in vivo experiments for immunosafety and PD questions.
  • Will routinely perform multi-color flow cytometry experiments and multiplex cytokine analysis.
  • Characterize compounds in different cellular assays.
  • Share knowledge by active collaboration with other scientists and associates inside and outside the group.
  • Attend and present at internal meetings.
  • Keep accurate electronic records.
  • Contribute to the organization of the laboratory as assigned.

Who You Are:

  • You are a motivated research assistant with excellent scientific, communication and organizational skills, fully committed to team effort but able to work in an independent fashion.
  • For this position we expect the following qualifications:
  • Senior research associate in a life science discipline (e.g. cell biology, immunology).
  • 3+ years of experience in a research lab.
  • You are passionate for your work and have the ability to work to tight timelines.
  • Experience in in-vitro immune cell assays, including whole blood as well as PBMC isolation, cultivation and differentiation.
  • Good experience in multi-color flow cytometry, ideally experience in the independent design and troubleshooting of multi-color flow cytometry panels on BD instruments.
  • Prior experience in cytokine analysis (ELISA or multiplex methods).
  • Experience in compound screening in cell-based assays is required.
  • Experience in immunology, cancer biology and/or drug discovery is a plus.
  • Hands on experience with in vivo experimentation and 3R principles.
  • Prior experience in the pharmaceutical industry would be a plus.
  • Familiarity with standard lab equipment and data analysis software (FlowJo, Prism) is required.
  • Should be able to conduct and document original research in an independent fashion.
  • Excellent oral and written communication skills in English are required.

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way.

We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

At Roche, we believe it’s urgent to deliver medical solutions right now – even as we develop innovations for the future. We are passionate about transforming patients’ lives and we are fearless in both decision and action. And we believe that good business means a better world.

That is why we come to work every single day. We commit ourselves to scientific rigor, unassailable ethics, and access to medical innovations for all. We do this today to build a better tomorrow.

You would like to play an active part in the way how we assess our innovative therapeutic protein drugs in the future?

As part of the Roche Pharma Research and Early Development (pRED) organisation in Basel, within the unit Pharmaceutical Sciences, the "Comparative Pharmacology and Toxicology" Team is supporting the research efforts of pRED through high quality, flexible and specialized performance of in vivo studies and management of and care for laboratory animals, hereby ensuring regulatory compliance with the Swiss Animal Protection Regulations and AAALACi.

In this team you would be in charge of the following responsibilities:

  • Support the ocular safety team in conduction of in vivo studies including ocular imaging techniques
  • Participate in exploratory research studies within a multidisciplinary team, manage and process large data sets
  • Execute in vivo pharmacology studies including safety, efficacy and pharmacokinetic/ pharmacodynamics (PK/PD) studies in rodents
  • Analysis and documentation of data in a professional format
  • Perform routine necropsy procedures
  • Work independently and plan in vivo studies within a matrix research environment to coordinate with other functions
  • Responsible for compliance with animal welfare regulation

You own the following qualifications:

  • BSc or equivalent technical degree in biology or life science

  • Training in animal handling according to Swiss legislation in Animal Welfare (LTK1)
  • Communication fluently in English
  • You are a team player, eager to learn and motivated to develop and establish new techniques

Are you ready to apply? We want someone who thinks beyond the job offered - someone who knows that this position can be a rare springboard to many other opportunities at Roche.

Roche embraces diversity and equal opportunity in a serious way. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Roche is an equal opportunity employer.

For non-EU / EFTA citizens: Please state your eligibility status to work in Switzerland (e.g. B-Permit, C-Permit) and note that if you do not own a valid Swiss work permit, Roche cannot guarantee your final employment due to  authority regulations.

** PhD's and post docs''s graduated cannot be considered for associate roles in Roche pRED.

21.10.2019
Position with re­spon­si­bil­i­ties, 100%

Contact

F. Hoffmann-La Roche AG
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