Principal scientist - antibody engineering

10.10.2019 | Employee | 100%

Principal scientist - antibody engineering

COMPANY OVERVIEW

Glenmark Innovation is a wholly owned subsidiary of Glenmark Pharmaceuticals and is based in the U.S. It has an independent board and a new Chief Executive Officer. The new company will provide an enhanced focus to the Glenmark innovation business and help accelerate the pipeline towards commercialization.

Our Swiss operation encompasses two biological R&D Centers and a GMP manufacturing facility and focuses on the discovery and development of novel biological entities and drugs comprising monoclonal antibodies and proprietary bispecific format in the field of immune-oncology and autoimmune diseases.

Overall we currently have three assets in the clinic in various stages of development from Phase 1 to Phase 2b. We also have multiple discovery programs based on our proprietary technology platform, BEAT® (Bispecific Engagement by Antibodies based on the T cell receptor). Our molecules and drugs under developments target treatment among others of HER2 positive cancers, multiple myeloma and other malignancies of hematopoietic origin, as well as a variety of solid tumors.

We are looking for highly motivated people who thrive on being challenged and working in an agile, collaborative and multicultural environment to join our multidisciplinary discovery team and play a key role in conducting rigorous, cutting-edge science.

To partake in execution and enrichment of our ambitious pipeline of projects, we are seeking to hire a

PRINCIPAL SCIENTIST - ANTIBODY ENGINEERING

ROLE OVERVIEW

We invite a knowledgeable scientist experienced in antibody rational design, protein design, protein biophysical characterization and antibody developability assessment to participate in the design of antibodies and bi/multispecific antibodies from inception to lead selection for industrialization. You will mentor research officers and associates in the team.

RESPONSIBILITIES:

  • Lead/participate in the design, characterization and developability of bi/multispecific antibodies.
  • Participate in the development of innovative solutions to engineer and characterize antibodies and novel antibody formats.
  • Lead/participate in Fc engineering projects.
  • Support team to address complex processes and transition leads for industrialization.
  • Accomplish goals under project team timelines.
  • Interface with multiple discovery project and matrix teams across the organization.
  • Effectively manage projects and resources to maximize progress.

  • Effectively communicate research progress and opportunities to senior management.
  • Support publications in high-tier journals and present at international meetings.
  • Support a culture that embraces scientific excellence, continuous learning, and increasing. team's ability to deliver novel drug candidates.

EDUCATION AND DESIRED EXPERIENCE:

  • Ph.D. in Molecular Biology, Biochemistry, Structural Biology or related fields with at least 4 years of relevant industrial experience. Hands-on experience with making T cell and/or other immune cell engagers is preferred.
  • Thorough knowledge and practical experience in protein engineering, protein expression, protein-protein interaction techniques, protein structure, and biophysical methods. Experience with Fc engineering is a plus.
  • Demonstrated experience in managing research technicians.
  • Demonstrated experience with bioinformatics techniques and 3D structure visualization software.
  • Experience in 3D antibody modelling is a plus.
  • Ability to work with flexibility in a changing and demanding environment.
  • Demonstrated success with problem analysis/solving, anticipation and proactivity.
  • Strong sense of discipline and initiative, exceptional planning and organization skills and a hands-on approach to work.
  • Fluency in English, both written and verbal is a must have.

LOCATION:

You will join us, a vibrant biotech community at the Biopôle (https://www.biopole.ch/ ) overlooking the beautiful shores of Geneva lake in Lausanne, Switzerland.

This is a rare opportunity to join our growing scientific team at the very start of something special. You will become a part of the foundation of a new company making yourself an imprint

10.10.2019
Employee, 100%

Required minimum profile

  • Ph.D. in Molecular Biology, Biochemistry, Structural Biology or related fields with at least 4 years of relevant industrial experience.
  • practical experience in protein engineering, protein expression, protein-protein interaction techniques, protein structure, and biophysical methods
  • Demonstrated experience with bioinformatics techniques and 3D structure visualization software
  • Fluency in English, both written and verbal is a must have

Contact

Glenmark Pharmaceuticals S.A.
Inessa Duerst
Route de la Corniche 5
1066 Epalinges
Glenmark Pharmaceuticals S.A.
Chemin de la Combeta 5
La Chaux-de-Fonds

Industry

Biotechnology / Chemistry / Pharmaceutical

Year of foundation

2004
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