Principal scientist – ANTIBODY/PROTEIN analytics

10.10.2019 | Employee | 100%

Principal scientist – ANTIBODY/PROTEIN analytics

COMPANY OVERVIEW

Glenmark Innovation is a wholly owned subsidiary of Glenmark Pharmaceuticals and is based in the U.S. It has an independent board and a new Chief Executive Officer. The new company will provide an enhanced focus to the Glenmark innovation business and help accelerate the pipeline towards commercialization.

Our Swiss operation encompasses two biological R&D Centers and a GMP manufacturing facility and focuses on the discovery and development of novel biological entities and drugs comprising monoclonal antibodies and proprietary bispecific format in the field of immune-oncology and autoimmune diseases.

Overall we currently have three assets in the clinic in various stages of development from Phase 1 to Phase 2b. We also have multiple discovery programs based on our proprietary technology platform, BEAT® (Bispecific Engagement by Antibodies based on the T cell receptor). Our molecules and drugs under developments target treatment among others of HER2 positive cancers, multiple myeloma and other malignancies of hematopoietic origin, as well as a variety of solid tumors.

We are looking for highly motivated people who thrive on being challenged and working in an agile, collaborative and multicultural environment to join our multidisciplinary discovery team and play a key role in conducting rigorous, cutting-edge science.

To partake in execution and enrichment of our ambitious pipeline of projects, we are seeking to hire a

PRINCIPAL SCIENTIST - ANTIBODY/PROTEIN ANALYTICS

ROLE OVERVIEW

To support discovery and developability assessment activities we invite an interactive and creative individual who possesses substantial scientific knowledge as well as a demonstrated practical experience in protein engineering with focus on purification and characterization of protein therapeutics including antigens, antibodies, and bi/multispecific antibodies. The position is laboratory-based within the Protein Sciences group.

RESPONSIBILITIES:

  • Design and implement experiments for analytical characterization of antigens and novel antibody formats (bi/multispecific antibodies).
  • Perform analytical studies to discovery research activities.
  • Be a hands-on presence in the laboratory.
  • Specify, purchase, install and maintain analytical equipment.
  • Write formal technical reports, methods and procedures.
  • Train personnel on use of equipment and methods.
  • Support data and method transfer within/outside the department.

  • Accomplish goals under project team timelines.
  • Interface with multiple discovery project and matrix teams across the organization.
  • Effectively manage projects and resources to maximize progress.
  • Effectively communicate research progress and opportunities to senior management.
  • Support publications in high-tier journals and present at international meetings.
  • Support a culture that embraces scientific excellence, continuous learning, and increasing team's ability to deliver novel drug candidates.

EDUCATION AND DESIRED EXPERIENCE:

  • Ph.D. in Analytical Chemistry, Biochemistry or related discipline (e.g. Chemistry, structural biology) with demonstrated analytical capabilities and at least 5 years of relevant industrial experience.
  • Strong knowledge of therapeutic proteins/antibodies analytics and characterization for therapeutic drug discovery.
  • A demonstrated record of scientific accomplishment, laboratory experimentation, publications and presentations.
  • Extensive laboratory experience with and an in-depth knowledge of analytical method development and implementation including: HPLC (RP, SEC, and HIC), capillary electrophoresis (CE), capillary isoelectric focusing (cIEF), glycan analysis, differential scanning calorimetry (DSC), and diffraction based analytical methods such as dynamic light scattering (DLS) and multiple angle light scattering coupled to size-exclusion chromatography (SEC-MALS).
  • Must possess extensive understanding of mass spectrometric techniques and data analysis.
  • Strong problem-solving and troubleshooting skills. A working knowledge of the repair and maintenance of standard analytical equipment is desired.
  • Strong capabilities in experimental design, execution and data interpretation.
  • Ability to work independently.
  • Ability to provide scientific guidance, leadership and training to others within/outside the department.
  • Fluency in English, both written and verbal is a must.

Location:

You will join us, a vibrant biotech community at the Biopôle (https://www.biopole.ch/ ) overlooking the beautiful shores of Geneva lake in Lausanne, Switzerland.

Now it is a rare opportunity to join our growing scientific team at the very start of something special. You will become a part of the foundation of a new company making yourself an imprint

10.10.2019
Employee, 100%

Required minimum profile

  • • Ph.D. in Analytical Chemistry, Biochemistry or related discipline (e.g. Chemistry, structural biology) with demonstrated analytical capabilities and at least 5 years of relevant industrial experience.
  • • Strong knowledge of therapeutic proteins/antibodies analytics and characterization for therapeutic drug discovery
  • • Extensive laboratory experience with and an in-depth knowledge of analytical method development and implementation including: HPLC (RP, SEC, and HIC), capillary electrophoresis (CE), capillary isoelectric focusing (cIEF), glycan analysis, differential s
  • • Must possess extensive understanding of mass spectrometric techniques and data analysis
  • • Fluency in English, both written and verbal is a must

Contact

Glenmark Pharmaceuticals S.A.
Inessa Duerst
Route de la Corniche 5
1066 Epalinges
Glenmark Pharmaceuticals S.A.
Chemin de la Combeta 5
La Chaux-de-Fonds

Industry

Biotechnology / Chemistry / Pharmaceutical

Year of foundation

2004
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