PhD Position in Advanced Characterization of Soft and Hybrid Nanoparticles: Combining small-angle X-ray scattering (SAXS) and fluorescence cross-correlation spectroscopy (FCCS)
Empa, Materials Science and Technology
St. Gallen
Key information
- Publication date:24 July 2025
- Workload:100%
- Contract type:Permanent position
- Place of work:St. Gallen
Job summary
Join Empa, a leading research institution in materials science. Embrace an innovative work environment with excellent benefits.
Tasks
- Develop SAXS and FCCS methods for nanoparticle characterization.
- Investigate lipid nanoparticles and their interactions for therapeutics.
- Collaborate with partners to advance quantitative analysis methods.
Skills
- Master’s in Chemistry, Physics, or related field required.
- Experience in scattering methods like SAXS or FCCS preferred.
- Proficiency in data analysis using Python or MATLAB is desirable.
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Materials science and technology are our passion. With our cutting-edge research, Empa's around 1,100 employees make essential contributions to the well-being of society for a future worth living. Empa is a research institution of the ETH Domain.
PhD Position in Advanced Characterization of Soft and Hybrid Nanoparticles: Combining small-angle X-ray scattering (SAXS) and fluorescence cross-correlation spectroscopy (FCCS)
At Empa’s Centre for X-ray Analytics, we investigate bio-nano assemblies from lipid nanoparticles (LNPs) to polymer-based nanosystems using powerful analytical tools such as small-angle X-ray scattering (SAXS) and fluorescence cross-correlation spectroscopy (FCCS). Our goal is to bring quantitative insights into how soft-matter systems self-assemble and function, with a particular emphasis on DNA/RNA-LNPs for next-generation gene therapeutics.
Your tasks
This PhD position is part of a larger EU-funded project focused on the metrological characterization of nanoparticles for healthcare and industrial applications.
As a PhD candidate, you will:
- Develop and refine SAXS and FCCS methods to quantify size, concentration, density and internal structure of diverse nanoparticle systems.
- Investigate model particles such as liposomes, mesoporous silica and silver nanoparticles.
- Investigate RNA-LNP formulations for next-generation gene therapeutics, examining how lipid components and nucleic acids interact and self-assemble.
- Apply data analysis and modeling to deepen understanding of nanoparticle architectures, and contribute to standardization-relevant method development.
- Collaborate with academic partners and potential industrial contacts to implement, validate, and/or refine quantitative methods needed to overcome key challenges in nanoparticle characterization.
Your profile
- Master’s degree in Chemistry, Physics, Biophysics, Materials Science, or a related field.
- Strong interest or background in soft matter, self-assembly, or nanoparticle systems (e.g., lipid- or polymer-based).
- Quantitative mindset with good data analysis and problem-solving skills.
- Prior hands-on experience in scattering methods (SAXS, SANS) or correlation spectroscopy (FCS, FCCS) is a plus.
- Demonstrated competence in data analysis (e.g., in Python, MATLAB, or similar) or in analyzing scattering data is desirable.
- Proficiency in English (German is a plus).
- Enthusiasm to engage in multidisciplinary and international collaborations.
Our offer
We provide an international and stimulating research environment with excellent infrastructure for personal and professional development. You will be employed full-time (three years with the potential extension by one additional year) at Empa St. Gallen in the Bio-Nano Assembly research group, which is part of the Center for X-ray Analytics, the Laboratory for Biomimetic Membranes and Textiles and the Laboratory for Biointerfaces. This dynamic environment in the ETH Domain offers state-of-the-art facilities, expert mentorship, and an ideal platform to advance your scientific career.
Starting Date: As soon as possible or upon agreement.
We live a culture of inclusion and respect. We welcome all people who are interested in innovative, sustainable and meaningful activities - that's what counts.
We look forward to receiving your complete online application including a letter of motivation, CV, certificates, diplomas and contact details of two reference persons. Please submit these exclusively via our job portal. Applications by e-mail and by post will not be considered.
