Laborant:in / Technical Assistant/ Master / Intern Biologie / Biochemie 80-100%

Laborant:in / Technical Assistant/ Master / Intern Biologie / Biochemie 80-100%

Starting immediately or as negotiated

The Department of Biomedicine, University of Basel, Switzerland, invites qualified candidates to apply for a position as technical assistant in Biology, Biochemistry and Cancer Research. The candidate will join our multi-disciplinary team and focus on the development and performance of modern assays to evaluate bioactive molecules targeting major signaling pathways in cancer and inflammation.

The working place of the successful candidate is the Department of Biomedicine at Mattenstrasse 28, 4058 Basel.

Projects:
Main focus:

i) Targeting oncogenicity by covalent inhibitors, a project with a translational aspect.
For relevant recent publications see Borsari et al. (2022) J. Am. Chem. Soc. 144(14): 6326-6342 ; Bissegger et al. (2024) Chem. Sci. 15: 20274-20291
This project is flanked by a basic research project developing novel chemical probes and degraders to dissect mechanisms of adverse effects in cancer and metabolism.
For a summary of the latter see: p3.snf database

ii) In parallel we investigate the role of PI3K in allergy, metabolic control, obesity, diabetes and cancer.

Your position

• To design, execute and analyze biochemical, biophysical and cellular drug screening assays to evaluate small molecule inhibitors.
• Assays include imaging, TR-FRET, inhibitor/target interaction studies, cell culture, automated nanoLt dispensing and more.
• Subsequent analysis of results requires GraphPad Prism, KinTek Explorer (kinetic analysis), Excel, and Statistics.
• Work in a multi-disciplinary environment collaborating with cell biologists and chemists.
• Writing of reports and protocols.

Your profile

The successful candidate is a EFZ Laboratory technician (chemistry and biology) or holds a master in Biology, Biochemistry, Nanoscience or similar. Qualified interns will be considered.
Expertise with drug screening assays, cell culture and spectroscopic methods is of advantage. An interest for software-based analysis and ev. R-programming is welcome.
The ideal candidate is highly motivated, works independently, pays attention to experimental details, and ingrates rapidly in our team.

We offer you

The present infrastructure and extensive research equipment is state of the art. University of Basel is an equal opportunity employer. Salaries are according to the staff-regulations and depend on the qualifications and experience of the candidate.
The position will be initially for one year.