Research technician in biomedicine

The laboratory of the Department of Dermatology focuses on translational research in skin immunology, with a particular emphasis on immune profiling of human tissue samples. A central component of our work is transcriptomic-based analysis of skin biopsies and proteomics analysis of serum samples to support precision medicine approaches. We are seeking a research technician with strong molecular biology expertise, who will take primary responsibility for transcriptomic and proteomic workflows and contribute to additional laboratory tasks.

What you can expect

• Independent execution of transcriptomic and proteomic workflows (approx. 60-80%), including serum isolation and RNA extraction from human skin biopsies using TRIzol-based protocols
• RNA quality control (Nanodrop, Fragment Analyzer), sample preparation, and hybridization
• Operation of the nCounter Prep Station and Digital Analyzer, including coordination of runs with external collaborators
• Structured documentation of experimental metadata and generation of high-quality, reproducible transcriptomic datasets aligned with published immune module readouts
• Isolation, preservation, and experimental processing of human tissue samples; cell culture work with PBMCs, primary human cells, and cell lines (approx. 20-40%)
• Support of molecular and cellular assays (e.g. flow cytometry), general laboratory organization, and contribution to method optimization and implementation of new assays

Your Profile

• Diploma as a Biology Laboratory Technician or a Master's degree in Biomedical Sciences, Molecular Life Sciences, or an equivalent qualification
• Proven experience in molecular biology, ideally including RNA-based techniques
• Hands-on experience with transcriptomic platforms is a strong advantage
• Confident handling of human samples, sterile techniques, and laboratory safety standards
• High level of accuracy, reliability, strong documentation skills, and ability to work independently within established protocols
• Enthusiasm for translational research and teamwork; fluency in English and/or German, with flexibility to work outside standard hours when required by sample logistics

What we offer

• A technically demanding and scientifically meaningful role in translational skin immunology
• Responsibility for a core transcriptomics platform within the lab
• Close integration into ongoing research projects with clinical relevance
• Training opportunities and continued professional development
• A collaborative, motivated team and state-of-the-art infrastructure
• Opportunities for national and international scientific collaboration

Questions about the job?

For further information, please contact Nicole Bertschi Research Associate Stefanie Schärli PhD student

+41 31 632 48 36