PhD student position to study transcription-replication conflicts and genomic instability 100 %
Universität Bern
Bern
Key information
- Publication date:15 August 2025
- Workload:100%
- Place of work:Bern
Job summary
Join the University of Bern's research team on exciting cancer biology.
Tasks
- Investigate how PARPs prevent DNA damage in cells.
- Explore mechanisms of transcription-replication conflicts.
- Collaborate with experts in molecular and cell biology.
Skills
- Master's degree in progress or recently completed required.
- Experience with CRISPR/Cas9 and next-generation sequencing.
- Strong interest in cancer biology and genome stability.
Is this helpful?
A PhD student position is available at the University of Bern, Switzerland, to join the research group of Michalis Petropoulos, in collaboration with Sven Rottenberg (Vetsuisse Faculty and Bern Center for Precision Medicine).
Project Overview:
PARP inhibitors are being used to treat human cancers with homologous recombination deficiencies. We recently published on the role of PARP1 in preventing DNA damage in response to transcription-replication conflicts (Petropoulos et al., Nature, 2024).
Aufgaben
We are recruiting a PhD student to elucidate the molecular mechanisms by which PARPs detect transcription-replication conflicts and act to prevent induction of DNA damage in normal and cancer cells. The successful candidate will be co-supervised by Dr. Michalis Petropoulos, a newly recruited Group Leader at the University of Bern, and Prof. Sven Rottenberg, Director of the Institute of Animal Pathology, University of Bern.
Anforderungen
Applicants should be in the final stages of their Master's degree (with expected completion within the next few months) or have completed their degree within the past six months. We are seeking a highly motivated PhD candidate with a background in molecular and cell biology, and a strong interest in cancer biology and genome stability. Experience with techniques such as CRISPR/Cas9, high-content imaging, next-generation sequencing, or organoid models is an advantage but not required.
Wir bieten
How to apply:
Please send your application in ONE PdF File to E-Mail schreiben including:
- Your CV
- A motivation letter
- Names and contact details (or letters) of two academic references
