PhD Position in mitochondrial metabolism and quantitative imaging

Introduction

Mitochondria are much more than cellular powerhouses: they form a complex and dynamic network that functions as a metabolic and signalling hub. As a remnant of their bacterial origins, mitochondria retain a unique multi-copy circular genome (mtDNA), packaged into thousands of nucleoids coordinating virtually every physiological process.
Defective mtDNA regulation can cause a wide spectrum of human pathology, from fulminant metabolic disease to common age-related disorders. Although conventional wisdom dictates that cells across the human body similarly depend on mitochondrial function, each of these disorders affect unique constellations of organ systems. This remarkable tissue-specificity remains one of biology's most puzzling open questions.

Presentation

The Landoni Laboratory (landonilab.org) seeks to chart the dynamic processes orchestrating mtDNA maintenance and metabolic architecture. Through cutting-edge live imaging and integrative systems biology in alternative model organisms, we aim to understand how these mechanisms drive healthy tissue development, why their breakdown causes disease and ageing, and ultimately how to leverage them therapeutically. The Landoni lab is an emerging research group in the Department of Biomedical Sciences (DBS) at the University of Lausanne, embedded in one of Europe's most dynamic biomedical ecosystems at the interface of UNIL, EPFL, and the CHUV university hospital.

Job information

Expected start date in position : September 2026 or be agreed

Contract length : 1 year, renewable 2 x 2 years, maximum 5 years

Workplace : Lausanne, Bugnon - Department of Biomedical Sciences (DBS)

Your responsibilities

We are looking for a motivated PhD candidate to work at the intersection of organelle biology, metabolism, and physiology, using some of the most exciting tools in modern biomedical research. The ideal candidate has a collaborative and multidisciplinary outlook, and a curious and explorative mind.

Your qualifications

Candidates must be fluent in English and hold a Master's degree (or equivalent conferring PhD eligibility) in biomedicine, biology, chemistry, or a similar field which could bring novel perspectives to our research. Experience with microscopy, cell and molecular biology, or fish and nematode model organisms are advantageous.

What the position offers you

We offer a supportive and exciting research environment where your ideas matter and curiosity is the driver. We value diversity, creativity, inclusion, transparency, sustainability, outreach, humor, and quality of life. As an early member of an emerging lab, you will have the freedom to develop your own ideas, take ownership of your projects, and shape how we do science, all while engaging with the active DSB community. You will have access to world-class research and imaging infrastructure, a rich collaborative network spanning basic science and clinical medicine, and mentorship dedicated to your growth at every stage.
You will have the freedom to develop your own ideas, take ownership of your projects, and grow into an independent scientific thinker. As an early member of a young lab, you will have the unique opportunity to shape how we do science, while interacting with the active DSB community. You will have access to world-class research and imaging infrastructure, and a rich collaborative network spanning basic science and clinical medicine, with mentorship dedicated to your growth at every stage.
Outside the lab, Lausanne is a genuinely exciting place to live: a dynamic city buzzing with academics, athletes, and artists, exceptionally well connected to the rest of Europe. Sitting on the shores of Lac Léman, with the breathtaking Alps as a backdrop, it offers a remarkable blend of culture and nature. World-class cuisine, wine tasting on terraced vineyards, outstanding museums, performing arts and festivals year-round, and endless outdoor activities for every season: hiking, skiing, swimming, sailing, and paragliding, all just around the corner.
UNIL is a leading international research and teaching institution, committed to equality, diversity, and inclusion; an open and respectful environment conducive to personal development; working conditions that support work-life balance; and the active support of early-career researchers.

Contact for further information

More information: landonilab.org

Your application

Deadline : Until position is filled

How to apply : Submit a single PDF containing :

•    Motivation/cover letter (1 page max)
•    CV with publications and any outreach activities
•    Academic diplomas
•    Names and contact details of references

Please, send your full application in Word or PDF.
Only applications through this website will be taken into account.

Applications are reviewed on a rolling basis.
We thank you for your understanding.

Additional information

UNIL is committed to:
•    equality, diversity and inclusion within its community;
•    ensuring an open and respectful environment that is conducive to personal development;
•    offering working conditions that facilitate work-life balance;
•    supporting early career researchers.